ABSTRACT
Objective: To understand the occupation burnout of community medical staff during epidemic and explore the influencing factors, so as to improve the mental health level of medical staff. Methods: Totally 843 community medical staff in the central urban area were studied. They were surveyed by a face-to-face with the questionnaire of JCQ, ERI and MBI. Results: Totally 835 valid questionnaires were recovered with an effective response rate of 99.1%. JCQ mode showed that the detection rate of occupational stress was 42.5%. The ERI mode showed the detection rate of occupational stress was 34.0%. The incidence of job burnout was 50.8%, of which the incidence of mild and moderate job burnout was 42.2% and the incidence of severe job burnout was 8.6%. The logistic regression analysis showed that the risk of job burnout of community medical staff was increased (P < 0.05), OR = 1.546 (aged 40 to < 50 years vs. aged < 30 years), OR = 1.506 to 1.707 (working time more than 10 years vs. less than 10 years), OR = 2.085 (working in public health departments vs. in clinical departments), OR = 2.408 (working more than 50 hours per week vs. less than 40 hours per week), and OR = 1.811 (working with night shift vs. without night shift). Compared with those with monthly income < 3 000 yuan, exercise frequency < 1 time per week and sleep time < 6 h per day, those with monthly income > 3 000 yuan (OR = 0.098 - 0.133), exercise frequency 1 time per week(OR = 0.308 - 0.603) and sleep time 6 h per day(OR = 0.300 - 0.334) had a lower risk of job burnout (P < 0.05). The higher the scores of social support (OR = 0.667) and return(OR = 0.605), the lower the risk of burnout of community medical personnel(P < 0.05);the higher the scores of giving (OR = 2.468)and intrinsic input (OR = 1.549), the greater the risk of burnout of community medical personnel(P < 0.05). Conclusions: During the epidemic prevention and control period, there was a certain degree of job burnout among community medical personnel. We can strengthen the intervention from individuals, organizations and society aspects and reduce the job burnout of community medical personnel by improving the level of professional skills, reasonable scheduling, appropriate exercise, and strengthening psychological counseling.
ABSTRACT
RNA viruses generate defective viral genomes (DVGs) that can interfere with replication of the parental wild-type virus. To examine their therapeutic potential, we created a DVG by deleting the capsid-coding region of poliovirus. Strikingly, intraperitoneal or intranasal administration of this genome, which we termed eTIP1, elicits an antiviral response, inhibits replication, and protects mice from several RNA viruses, including enteroviruses, influenza, and SARS-CoV-2. While eTIP1 replication following intranasal administration is limited to the nasal cavity, its antiviral action extends non-cell-autonomously to the lungs. eTIP1 broad-spectrum antiviral effects are mediated by both local and distal type I interferon responses. Importantly, while a single eTIP1 dose protects animals from SARS-CoV-2 infection, it also stimulates production of SARS-CoV-2 neutralizing antibodies that afford long-lasting protection from SARS-CoV-2 reinfection. Thus, eTIP1 is a safe and effective broad-spectrum antiviral generating short- and long-term protection against SARS-CoV-2 and other respiratory infections in animal models.